TY - JOUR
T1 - Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala
T2 - Heterosynaptic induction mechanisms of late-LTP
AU - Frey, Sabine
AU - Bergado-Rosado, Jorge
AU - Seidenbecher, Thomas
AU - Pape, Hans Christian
AU - Frey, J. Uwe
PY - 2001/5/15
Y1 - 2001/5/15
N2 - The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and β-adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.
AB - The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and β-adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.
KW - Associative LTP
KW - Basolateral amygdala
KW - Dentate gyrus
KW - Heterosynaptic LTP
KW - Hippocampus
KW - Late-LTP
KW - Long-term potentiation
KW - Reinforcement
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UR - http://www.scopus.com/inward/citedby.url?scp=0035873541&partnerID=8YFLogxK
U2 - 10.1523/jneurosci.21-10-03697.2001
DO - 10.1523/jneurosci.21-10-03697.2001
M3 - Article
C2 - 11331399
AN - SCOPUS:0035873541
SN - 0270-6474
VL - 21
SP - 3697
EP - 3703
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 10
ER -