Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

Queen Henry-Okafor; Sean P. Collins; Cathy A. Jenkins; Karen F. Miller; David J. Maron; Allen J. Naftilan; Neal Weintraub; Gregory J. Fermann; John Mcpherson; Santosh Menon; Douglas B. Sawyer; Alan B. Storrow

doi:10.2174/1875318301205010009

Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

Queen Henry-Okafor, Sean P. Collins, Cathy A. Jenkins, Karen F. Miller, David J. Maron, Allen J. Naftilan, Neal Weintraub, Gregory J. Fermann, John Mcpherson, Santosh Menon, Douglas B. Sawyer, Alan B. Storrow

Cardiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Open Biomarkers Journal
Volume	5
Issue number	1
DOIs	https://doi.org/10.2174/1875318301205010009
State	Published - 2012

Keywords

Acute heart failure
B-type natriuretic peptide
Prognostic outcomes
Uric acid

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Biochemistry
Biochemistry, medical

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10.2174/1875318301205010009

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Henry-Okafor, Q., Collins, S. P., Jenkins, C. A., Miller, K. F., Maron, D. J., Naftilan, A. J., Weintraub, N., Fermann, G. J., Mcpherson, J., Menon, S., Sawyer, D. B., & Storrow, A. B. (2012). Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure. Open Biomarkers Journal, 5(1), 9-15. https://doi.org/10.2174/1875318301205010009

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title = "Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure",

abstract = "Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.",

keywords = "Acute heart failure, B-type natriuretic peptide, Prognostic outcomes, Uric acid",

author = "Queen Henry-Okafor and Collins, {Sean P.} and Jenkins, {Cathy A.} and Miller, {Karen F.} and Maron, {David J.} and Naftilan, {Allen J.} and Neal Weintraub and Fermann, {Gregory J.} and John Mcpherson and Santosh Menon and Sawyer, {Douglas B.} and Storrow, {Alan B.}",

year = "2012",

doi = "10.2174/1875318301205010009",

language = "English (US)",

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T1 - Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

AU - Henry-Okafor, Queen

AU - Collins, Sean P.

AU - Jenkins, Cathy A.

AU - Miller, Karen F.

AU - Maron, David J.

AU - Naftilan, Allen J.

AU - Weintraub, Neal

AU - Fermann, Gregory J.

AU - Mcpherson, John

AU - Menon, Santosh

AU - Sawyer, Douglas B.

AU - Storrow, Alan B.

PY - 2012

Y1 - 2012

N2 - Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

AB - Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

KW - Acute heart failure

KW - B-type natriuretic peptide

KW - Prognostic outcomes

KW - Uric acid

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Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

Abstract

Keywords

ASJC Scopus subject areas

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