TY - JOUR
T1 - Relationship of body composition to stress-induced pressure natriuresis in youth
AU - Wilson, Martha E.
AU - Harshfield, Gregory A.
AU - Ortiz, Luis
AU - Hanevold, Coral
AU - Kapuka, Gaston
AU - MacKey, Lynne
AU - Gillis, Delores
AU - Edmonds, Lesley
AU - Evans, Conner
N1 - Funding Information:
This study was supported by grants HL-59954 and HL-64225 from the National Institutes of Health and HL069999 from the National Heart, Lung, and Blood Institute.
PY - 2004/11
Y1 - 2004/11
N2 - The contribution of stress to obesity-related cardiovascular disease is uncertain. The purpose of this study was to examine the influence of body composition on stress-induced pressure natriuresis. Dual energy x-ray absorptiometry was performed in 127 African American and white youths to assess lean body mass (LBM), fat mass (FM), and total percentage of body fat (%BF). The stress protocol was comprised of a 2-h baseline period, 1-h video game competition stressor, and 2-h recovery period. Blood and urine samples were collected hourly and blood pressure (BP) was obtained at 15-min intervals. Both BP and urinary sodium excretion(U NaV) increased from baseline to stress and returned to prestress levels after stress (P =. 001 for each). The BP levels and changes were positively correlated with LBM. In contrast, levels and changes in sodium excretion U NaV were inversely correlated with FM and %BM. Multiple regression analyses that included ethnicity, sex, angiotensin II (Ang II), and measures of body composition in the models indicated the following: a) LBM was the best predictor of stress systolic BP and independently contributed with ethnicity to stress diastolic BP; b) ethnicity was the only independent predictor of the stress-related change in systolic and diastolic BP; c) LBM was the only independent predictor of the change in BP from stress to recovery for both systolic and diastolic BP; and d) total percent body fat accounted for 11.2% of the variance of stress U NaV, with Ang II contributing an additional 6.1%. Based on the results of this study, ethnicity and body composition are related to stress-induced pressure natriuresis.
AB - The contribution of stress to obesity-related cardiovascular disease is uncertain. The purpose of this study was to examine the influence of body composition on stress-induced pressure natriuresis. Dual energy x-ray absorptiometry was performed in 127 African American and white youths to assess lean body mass (LBM), fat mass (FM), and total percentage of body fat (%BF). The stress protocol was comprised of a 2-h baseline period, 1-h video game competition stressor, and 2-h recovery period. Blood and urine samples were collected hourly and blood pressure (BP) was obtained at 15-min intervals. Both BP and urinary sodium excretion(U NaV) increased from baseline to stress and returned to prestress levels after stress (P =. 001 for each). The BP levels and changes were positively correlated with LBM. In contrast, levels and changes in sodium excretion U NaV were inversely correlated with FM and %BM. Multiple regression analyses that included ethnicity, sex, angiotensin II (Ang II), and measures of body composition in the models indicated the following: a) LBM was the best predictor of stress systolic BP and independently contributed with ethnicity to stress diastolic BP; b) ethnicity was the only independent predictor of the stress-related change in systolic and diastolic BP; c) LBM was the only independent predictor of the change in BP from stress to recovery for both systolic and diastolic BP; and d) total percent body fat accounted for 11.2% of the variance of stress U NaV, with Ang II contributing an additional 6.1%. Based on the results of this study, ethnicity and body composition are related to stress-induced pressure natriuresis.
KW - Lean body mass
KW - blood pressure
KW - pressure natriuresis
KW - race
KW - stress
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U2 - 10.1016/j.amjhyper.2004.05.007
DO - 10.1016/j.amjhyper.2004.05.007
M3 - Article
C2 - 15533728
AN - SCOPUS:7944228146
SN - 0895-7061
VL - 17
SP - 1023
EP - 1028
JO - American journal of hypertension
JF - American journal of hypertension
IS - 11
ER -