Relaxation of rat tail artery to electrical stimulation

Anthony B. Ebeigbe, Robin D. Gantzos, R. Clinton Webb

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Rat tail artery strips relax in response to electrical stimulation (0.1-8Hz, 9V, 1.0msec) following contraction induced by norepinephrine (5.9xl0−7M). The relaxation is not altered by treatment of the strips with atropine, propranolol, tetrodotoxin or indomethacin nor by chemical denervation with 6-hydroxydopamine. Incubation of strips in calcium-free solution reduced the contractile response to norepinephrine and blocked relaxation in response to 4Hz electrical stimulation. Histamine antagonists (H2 receptor subclass: Cimetidine, metiamide) inhibited the relaxation to electrical stimulation in a dose-dependent manner. These results suggest that relaxation to electrical stimulation in rat tail artery is modulated by calcium and by the H2 subclass of histamine receptors.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalLife sciences
Issue number4
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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