TY - JOUR
T1 - Renal function in spontaneous hypertensive rats with insulin-exacerbated hypertension
AU - Mozaffari, Mahmood S.
AU - Roysommuti, Sanya
AU - Wyss, J. Michael
PY - 1997/4
Y1 - 1997/4
N2 - This study tests the hypothesis that in spontaneously hypertensive rats (SHR), insulin decreases natriuresis and diuresis and thereby contributes importantly to the hypertensive response to exogenous insulin administration. Seven week old SHR were given daily subcutaneous injections of either insulin (mixture of 5 U/Kg regular and 10 U/Kg NPH) or vehicle (isotonic saline). Within one week of treatment, systolic arterial pressure (SAP) was significantly higher in the insulin, compared to saline, treated SHR (184.2 ± 2.5 vs. 158.3 ± 4.0 mm Hg). However, twenty-four hour sodium and fluid excretion and the natriuretic and diuretic responses to an intravenous saline load were not affected either before or after the insulin-induced exacerbation of hypertension in SHR. Insulin treatment did not affect glomerular filtration rate, effective renal blood flow, or fractional excretion of Na+ or fluid. Therefore, our data do not support a major role for sodium and fluid retention in the insulin-induced exacerbation of hypertension in SHR.
AB - This study tests the hypothesis that in spontaneously hypertensive rats (SHR), insulin decreases natriuresis and diuresis and thereby contributes importantly to the hypertensive response to exogenous insulin administration. Seven week old SHR were given daily subcutaneous injections of either insulin (mixture of 5 U/Kg regular and 10 U/Kg NPH) or vehicle (isotonic saline). Within one week of treatment, systolic arterial pressure (SAP) was significantly higher in the insulin, compared to saline, treated SHR (184.2 ± 2.5 vs. 158.3 ± 4.0 mm Hg). However, twenty-four hour sodium and fluid excretion and the natriuretic and diuretic responses to an intravenous saline load were not affected either before or after the insulin-induced exacerbation of hypertension in SHR. Insulin treatment did not affect glomerular filtration rate, effective renal blood flow, or fractional excretion of Na+ or fluid. Therefore, our data do not support a major role for sodium and fluid retention in the insulin-induced exacerbation of hypertension in SHR.
KW - blood pressure
KW - glucose tolerance
KW - insulin
KW - natriuretic
KW - renal
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U2 - 10.3109/10641969709080821
DO - 10.3109/10641969709080821
M3 - Article
C2 - 9107439
AN - SCOPUS:0030615316
SN - 1064-1963
VL - 19
SP - 313
EP - 329
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 3
ER -