Renin-angiotensin-aldosterone system in healthy subjects aged ten to eighteen years

Gregory A. Harshfield, Bruce S. Alpert, Derrick A. Pulliam

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We abtained normative data for plasma renin activity (PRA) and plasma aldosterone concentration from a biracial sample of 195 healthy, normotensive children and adolescents aged 10 to 18 years. The sample Included 119 boys and 76 girls, of whom 103 were black and 92 were white. The mean PRA value (±SD) was 2.52±1.95ng/ml per hour, with minimal and maximal values of 0.1 and 13.50 ng/ml per hour. The mean plasma aldosterone concentration was 12.56±8.59 ng/ml, with minimal and maximal values of 1.6 and 50.1 ng/ml. We also examined the effects of subject characteristics and electrolyte intake. The slope relating sodium excretion to PRA was negative and highly significant (slope=-0.01; p<0.003). The slope relating PRA to plasma aldosterone concentration was positive and highly significant (slope=1.59; p<0.0001). We did not observe differences in either variable as a function of age, sex, race, or family history of hypertension. These results suggest that differences based on race and family history of hypertension observed in adults are not present in youth.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
JournalThe Journal of Pediatrics
Issue number4
StatePublished - Apr 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Renin-angiotensin-aldosterone system in healthy subjects aged ten to eighteen years'. Together they form a unique fingerprint.

Cite this