Reproducibility of p3

Edward Y. Zamrini, Kimford J. Meador, William O. Thompson, Gregory P. Lee

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 μV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was ±20 ms for latency and ±4.63 μV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalInternational Journal of Neuroscience
Issue number1-2
StatePublished - 1991
Externally publishedYes


  • Auditory
  • Evoked potentials
  • Human

ASJC Scopus subject areas

  • General Neuroscience


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