TY - JOUR
T1 - Reproductive hormone exposure timing and ischemic heart disease
T2 - Complicated answers to a simple question
AU - Bairey Merz, C. Noel
AU - Shufelt, Chrisandra
AU - Johnson, B. Delia
AU - Azziz, Ricardo
AU - Braunstein, Glenn D.
N1 - Funding Information:
This work was supported by contracts from the National Heart, Lung and Blood Institutes , nos. N01-HV-68161 , N01-HV-68162 , N01-HV-68163 , N01-HV-68164 , a GCRC grant MO1-RR00425 from the National Center for Research Resources , and grants from the Gustavus and Louis Pfeiffer Research Foundation , Denville, New Jersey, The Women's Guild of Cedars-Sinai Medical Center , Los Angeles, California, and The Ladies Hospital Aid Society of Western Pennsylvania , Pittsburgh, Pennsylvania, the Edythe L. Broad Women's Heart Research Fellowship, Cedars-Sinai Medical Center, Los Angeles, California, and the Barbra Streisand Women's Cardiovascular Research and Education Program, Cedars-Sinai Medical Center, Los Angeles.
PY - 2010/4
Y1 - 2010/4
N2 - The current literature, combined with improved methodology in the WISE study, suggests that there is a beneficial relation between HT use and IHD in peri- and early postmenopausal women. Our results are also consistent with recent clinical trials that have failed to show benefit of HT initiation in older postmenopausal women, either for angiographic coronary disease or cardiac events. Overall, our data suggest that the anti-atherosclerotic effect of HT, if present, may be age-dependent and primarily evident in relatively younger peri- and early postmenopausal women.
AB - The current literature, combined with improved methodology in the WISE study, suggests that there is a beneficial relation between HT use and IHD in peri- and early postmenopausal women. Our results are also consistent with recent clinical trials that have failed to show benefit of HT initiation in older postmenopausal women, either for angiographic coronary disease or cardiac events. Overall, our data suggest that the anti-atherosclerotic effect of HT, if present, may be age-dependent and primarily evident in relatively younger peri- and early postmenopausal women.
KW - Hormone
KW - Ischemic heart disease
KW - Reproductive
UR - http://www.scopus.com/inward/record.url?scp=77649336556&partnerID=8YFLogxK
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U2 - 10.1016/j.maturitas.2010.01.003
DO - 10.1016/j.maturitas.2010.01.003
M3 - Editorial
C2 - 20089376
AN - SCOPUS:77649336556
SN - 0378-5122
VL - 65
SP - 297
EP - 298
JO - Maturitas
JF - Maturitas
IS - 4
ER -