Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: Minocycline

Keyphrases

• Acute Ischemic Stroke 100%
• Minocycline 100%
• Tissue Plasminogen Activator (t-PA) 100%
• Old Drugs 100%
• Repurposing 100%
• Intracerebral Hemorrhage 50%
• Clinical Trials 16%
• Ischemic Stroke 16%
• Efficacy Data 16%
• Stroke Model 16%
• Underutilization 16%
• Matrix metalloproteinase-9 (MMP-9) 16%
• Symptom Onset 16%
• Phase II Trial 16%
• Safety Data 16%
• Anti-inflammatory Agents 16%
• Neuroprotective Agents 16%
• PARP Inhibitor (PARPi) 16%
• United States Food 16%
• Broad-spectrum Antibiotics 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Brain Ischemia 100%
• Minocycline 100%
• Tissue Plasminogen Activator 100%
• Repurposing 100%
• Brain Hemorrhage 50%
• Clinical Trial 16%
• Antibiotic Agent 16%
• Symptom 16%
• Biological Marker 16%
• Neuroprotective Agent 16%
• Gelatinase B 16%
• Antiinflammatory Agent 16%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 16%