TY - JOUR
T1 - Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
AU - Moskophidis, Demetrius
AU - Battegay, Manuel
AU - Bruendler, Marie Anne
AU - Laine, Elisabeth
AU - Gresser, Ion
AU - Zinkernagel, Rolf M.
PY - 1994/3
Y1 - 1994/3
N2 - The susceptibility to alpha/beta interferon (IFN-α/β) or to gamma interferon (IFN-γ) of various lymphocytic choriomeningitis virus (LCMV) strains was evaluated in C57BL/6 mice and in various cell lines. Anti-IFN-γ treatment in vivo revealed that the LCMV strains Armstrong, Aggressive, and WE were most susceptible to IFN-γ whereas Traub, CI 13-Armstrong, and Docile were resistant. The same pattern of susceptibility to recombinant IFN-γ was observed in vitro. In vivo treatment with anti-IFN-α/β showed a sizeable increase in replication of Aggressive, Armstrong, and WE; effects were less pronounced for Docile, CI 13-Armstrong, or Traub. Correspondingly, WE, Armstrong, and Aggressive were all relatively sensitive to purified IFN- α/β in vitro, and CI 13-Armstrong, Docile, and Traub were more resistant. Overall, there was a good correlation between the capacity of LCMV strains to establish a persistent infection in adult immunocompetent mice and their relative resistance to IFN-γ and IFN-α/β.
AB - The susceptibility to alpha/beta interferon (IFN-α/β) or to gamma interferon (IFN-γ) of various lymphocytic choriomeningitis virus (LCMV) strains was evaluated in C57BL/6 mice and in various cell lines. Anti-IFN-γ treatment in vivo revealed that the LCMV strains Armstrong, Aggressive, and WE were most susceptible to IFN-γ whereas Traub, CI 13-Armstrong, and Docile were resistant. The same pattern of susceptibility to recombinant IFN-γ was observed in vitro. In vivo treatment with anti-IFN-α/β showed a sizeable increase in replication of Aggressive, Armstrong, and WE; effects were less pronounced for Docile, CI 13-Armstrong, or Traub. Correspondingly, WE, Armstrong, and Aggressive were all relatively sensitive to purified IFN- α/β in vitro, and CI 13-Armstrong, Docile, and Traub were more resistant. Overall, there was a good correlation between the capacity of LCMV strains to establish a persistent infection in adult immunocompetent mice and their relative resistance to IFN-γ and IFN-α/β.
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U2 - 10.1128/jvi.68.3.1951-1955.1994
DO - 10.1128/jvi.68.3.1951-1955.1994
M3 - Article
C2 - 8107255
AN - SCOPUS:0027958330
SN - 0022-538X
VL - 68
SP - 1951
EP - 1955
JO - Journal of Virology
JF - Journal of Virology
IS - 3
ER -