Response of pulpal blood flow to intra-arterial infusion of endothelin

Thomas M. Gilbert, David H. Pashley, Ronald W. Anderson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Laser Doppler flowmetry was used to determine the effect of the vasoconstrictor endothelin 1 (ET-1) on the pulpal blood flow of intact dogs' teeth during mandibular arterial infusion. ET-1 produced a profound decrease in pulpal blood flow of a relatively long duration at lower doses than similar infusions of norepinephrine. The decrease in pulpal blood flow in response to ET-1 was partially attenuated by the calcium channel blocker nifedipine. These findings demonstrate the presence of receptors for ET-1 in the microvasculature of the dental pulp and suggests that ET-1 may function in the local control of the pulpal microcirculation.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalJournal of endodontics
Issue number5
StatePublished - May 1992
Externally publishedYes

ASJC Scopus subject areas

  • General Dentistry


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