Abstract
Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin-deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (T H17)/T H1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.
Original language | English (US) |
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Pages (from-to) | 405b |
Journal | Science |
Volume | 333 |
Issue number | 6041 |
DOIs |
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State | Published - Jul 22 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- General