Restoration of tumor suppressor functions by small-molecule inhibitors

Slovénie Pyndiah; Daitoku Sakamuro

doi:10.4161/23723556.2014.991225

Restoration of tumor suppressor functions by small-molecule inhibitors

Slovénie Pyndiah, Daitoku Sakamuro

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

Original language	English (US)
Article number	e991225
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.991225
State	Published - Jul 3 2015

Keywords

BIN1
RB1
p53
small-molecule inhibitor
tumor suppressor

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723556.2014.991225

Cite this

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title = "Restoration of tumor suppressor functions by small-molecule inhibitors",

abstract = "Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.",

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author = "Slov{\'e}nie Pyndiah and Daitoku Sakamuro",

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AU - Sakamuro, Daitoku

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Y1 - 2015/7/3

N2 - Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

AB - Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

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Restoration of tumor suppressor functions by small-molecule inhibitors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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