Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

Mehmet Cansev; Ismail H. Ulus; Lei Wang; Timothy J. Maher; Richard J. Wurtman

doi:10.1016/j.neures.2008.07.005

Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

Mehmet Cansev, Ismail H. Ulus, Lei Wang, Timothy J. Maher, Richard J. Wurtman

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.

Original language	English (US)
Pages (from-to)	206-209
Number of pages	4
Journal	Neuroscience Research
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.neures.2008.07.005
State	Published - Nov 2008
Externally published	Yes

Keywords

Docosahexaenoic acid
Dopamine
Parkinson's disease
Synapse
Tyrosine hydroxylase activity
Uridine

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neures.2008.07.005

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title = "Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease",

abstract = "Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.",

keywords = "Docosahexaenoic acid, Dopamine, Parkinson's disease, Synapse, Tyrosine hydroxylase activity, Uridine",

author = "Mehmet Cansev and Ulus, {Ismail H.} and Lei Wang and Maher, {Timothy J.} and Wurtman, {Richard J.}",

note = "Funding Information: These studies were supported in part by grants from the National Institutes of Health (MH-28783), the Center for Brain Sciences and Metabolism Charitable Trust, and the Turkish Academy of Sciences (IH Ulus).",

year = "2008",

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doi = "10.1016/j.neures.2008.07.005",

language = "English (US)",

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AU - Ulus, Ismail H.

AU - Wang, Lei

AU - Maher, Timothy J.

AU - Wurtman, Richard J.

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PY - 2008/11

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N2 - Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.

AB - Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.

KW - Docosahexaenoic acid

KW - Dopamine

KW - Parkinson's disease

KW - Synapse

KW - Tyrosine hydroxylase activity

KW - Uridine

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Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

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