Results of lesional vs. nonlesional frontal lobe epilepsy surgery

J. R. Smith, M. R. Lee, D. W. King, A. M. Murro, Y. D. Park, G. P. Lee, D. W. Loring, K. J. Meador, R. Harp

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61 Scopus citations


Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalStereotactic and Functional Neurosurgery
Issue number1-4
StatePublished - 1997


  • Epilepsy
  • Frontal lobe
  • Invasive localization
  • Long-term outcome
  • Outcome
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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