Retinal Gangliosides in RCS Mutant Rats

Thomas N. Seyfried; Robert K. Yu; Nobuko Miyazawa; Yin‐Lok ‐L Lai

doi:10.1111/j.1471-4159.1982.tb04735.x

Retinal Gangliosides in RCS Mutant Rats

Thomas N. Seyfried, Robert K. Yu, Nobuko Miyazawa, Yin‐Lok ‐L Lai

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Abstract: The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, G_D3, is discussed.

Original language	English (US)
Pages (from-to)	277-279
Number of pages	3
Journal	Journal of Neurochemistry
Volume	39
Issue number	1
DOIs	https://doi.org/10.1111/j.1471-4159.1982.tb04735.x
State	Published - Jul 1982
Externally published	Yes

Keywords

G
Gangliosides
Rat
Retina

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1982.tb04735.x

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abstract = "Abstract: The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, GD3, is discussed.",

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AU - Yu, Robert K.

AU - Miyazawa, Nobuko

AU - Lai, Yin‐Lok ‐L

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N2 - Abstract: The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, GD3, is discussed.

AB - Abstract: The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, GD3, is discussed.

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Retinal Gangliosides in RCS Mutant Rats

Abstract

Keywords

ASJC Scopus subject areas

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