TY - JOUR
T1 - Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages
AU - Manicassamy, Santhakumar
AU - Pulendran, Bali
N1 - Funding Information:
BP and SM were supported by the National Institutes of Health AI048638, AI05726601, DK057665, U54 AI057157 and AI-50019.
PY - 2009/2
Y1 - 2009/2
N2 - Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.
AB - Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.
KW - Dendritic cells
KW - Macrophages
KW - Retinoic acid
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U2 - 10.1016/j.smim.2008.07.007
DO - 10.1016/j.smim.2008.07.007
M3 - Review article
C2 - 18778953
AN - SCOPUS:56249130033
SN - 1044-5323
VL - 21
SP - 22
EP - 27
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 1
ER -