TY - JOUR
T1 - Revisiting Transcranial Light Stimulation as a Stroke Therapeutic—Hurdles and Opportunities
AU - Feng, Wuwei
AU - Domeracki, Alexis
AU - Park, Christine
AU - Shah, Shreyansh
AU - Chhatbar, Pratik Y.
AU - Pawar, Swaroop
AU - Chang, Cherylee
AU - Hsu, Po Chun
AU - Richardson, Eric
AU - Hasan, David
AU - Sokhadze, Estate
AU - Zhang, Quanguang
AU - Liu, Hanli
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.
AB - Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.
KW - Cerebroprotection
KW - Ischemic stroke
KW - Near-infrared laser therapy
KW - Noninvasive brain stimulation
KW - Stroke recovery
KW - Transcranial light stimulation
UR - https://www.scopus.com/pages/publications/85141732171
UR - https://www.scopus.com/pages/publications/85141732171#tab=citedBy
U2 - 10.1007/s12975-022-01103-7
DO - 10.1007/s12975-022-01103-7
M3 - Review article
C2 - 36369294
AN - SCOPUS:85141732171
SN - 1868-4483
VL - 14
SP - 854
EP - 862
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 6
ER -