Revisiting vitamin C in cancer therapy: Is "C" for cure, or just wishful thinking?

Fei Li, Lin Zhang, Shou Ching Tang

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations


We devoted this short piece to highlight one recent article published in Science, which revisited the anti-cancer efficacy of high-dose vitamin C. Using isogeneic KRAS- and BRAF-mutated colorectal cell lines, the authors were able to demonstrate selective anti-tumor effects among the KRAS- and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin C. Their elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake, leading to lethal accumulation of reactive oxygen species (ROS). This report will certainly rekindle enthusiasm in revisiting the case of vitamin C, pushing for more definitive cancer therapy trials.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalGenes and Diseases
Issue number1
StatePublished - Mar 1 2016
Externally publishedYes


  • BRAF
  • Cancer
  • Chemotherapy
  • KRAS
  • Vitamin C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology


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