RhoA/Rho-kinase: A novel player in the regulation of penile erection

K. Chitaley; R. C. Webb; T. M. Mills

doi:10.1038/sj.ijir.3900647

RhoA/Rho-kinase: A novel player in the regulation of penile erection

K. Chitaley, R. C. Webb, T. M. Mills

Physiology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Current research has centered around the role of nitric oxide in the stimulation of cavernosal vasodilation and erection. However, recent evidence from our lab details the importance of endogenous vasoconstrictor mechanisms in maintaining a flaccid penile state, and further demonstrates that the inhibition of endogenous vasoconstriction is sufficient to stimulate erection in a rat model. In this article, we suggest inhibition of endogenous vasoconstriction as a potential therapeutic avenue in the treatment of erectile dysfunction. We also speculate on potential physiologic mechanisms by which endogenous vasoconstriction is inhibited in order for arousal-initiated vasorelaxation, and erection, to occur.

Original language	English (US)
Pages (from-to)	67-72
Number of pages	6
Journal	International journal of impotence research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1038/sj.ijir.3900647
State	Published - 2001

Keywords

Erectile dysfunction
Nitric oxide
Rho-kinase

ASJC Scopus subject areas

Urology

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abstract = "Current research has centered around the role of nitric oxide in the stimulation of cavernosal vasodilation and erection. However, recent evidence from our lab details the importance of endogenous vasoconstrictor mechanisms in maintaining a flaccid penile state, and further demonstrates that the inhibition of endogenous vasoconstriction is sufficient to stimulate erection in a rat model. In this article, we suggest inhibition of endogenous vasoconstriction as a potential therapeutic avenue in the treatment of erectile dysfunction. We also speculate on potential physiologic mechanisms by which endogenous vasoconstriction is inhibited in order for arousal-initiated vasorelaxation, and erection, to occur.",

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RhoA/Rho-kinase: A novel player in the regulation of penile erection

Abstract

Keywords

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