Abstract
Background: Barrett’s esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective: The objective of this article is to determine the degree of histologic BE risk difference between AA and nHw. Methods: PubMed, Web of Science and EMBASE were searched for studies reporting histologic BE in AA/nHw for inclusion. Pooled odds ratios (ORs) with risk estimates of histologic BE occurrence between AA/nHw were calculated along with 95% confidence intervals (CIs). Forest plots were used to quantify heterogeneity. Funnel plots and the Cochrane Collaboration Risk of Bias tool were used to assess bias risk. Results: Eight studies reported BE histologic confirmation in AA/nHw. Analysis demonstrated a nearly 400% increased histologic BE risk in nHw patients compared to AA (OR 3.949, 95% CI 3.069–5.082). In the model without the case-control study, histologic BE risk remained elevated at approximately 360% in nHw compared to AA (OR 3.618, 95% CI 2.769–4.726). Heterogeneity was not present in either model. Risk of bias was significant. Conclusions: Histologic BE risk is elevated in nHw by 3.6–4 times compared to AA. Investigation into understanding any clinical, molecular or genetic mechanisms underlying this risk disparity is warranted.
Original language | English (US) |
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Pages (from-to) | 22-28 |
Number of pages | 7 |
Journal | United European Gastroenterology Journal |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2018 |
Keywords
- African Americans
- Barrett’s esophagus
- ethnicity
- meta-analysis
- risk
ASJC Scopus subject areas
- Oncology
- Gastroenterology