Rodent models of AKI-CKD transition

Ying Fu, Chengyuan Tang, Juan Cai, Guochun Chen, Dongshan Zhang, Zheng Dong

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations


Acute kidney injury (AKI) is a contributing factor in the development and progression of chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI-CKD transition remains largely unclear. Animal models recapitulating this process are crucial to the research of the pathophysiology of AKI-CKD transition and the development of effective therapeutics. In this review, we present the commonly used rodent models of AKI-CKD transition, including bilateral ischemia-reperfusion injury (IRI), unilateral IRI, unilateral IRI with contralateral nephrectomy, multiple episodes of IRI, and repeated treatment of low-dose cisplatin, diphtheria toxin, aristolochic acid, or folic acid. The main merits and pitfalls of these models are also discussed. This review provides helpful information for establishing reliable and clinically relevant models for studying post-AKI development of chronic renal pathologies and the progression to CKD.

Original languageEnglish (US)
Pages (from-to)F1098-F1106
JournalAmerican Journal of Physiology - Renal Physiology
Issue number4
StatePublished - Oct 5 2018


  • Acute kidney injury
  • Chronic kidney disease
  • Cisplatin
  • Fibrosis
  • Ischemia
  • Model
  • Nephrotoxicity

ASJC Scopus subject areas

  • Physiology
  • Urology


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