Role of adenosine in diabetic retinopathy

Gregory I. Liou; Saif Ahmad; Mohammad Naime; Nadeem Fatteh; Ahmed S. Ibrahim

doi:10.1007/s12177-011-9067-5

Role of adenosine in diabetic retinopathy

Gregory I. Liou, Saif Ahmad, Mohammad Naime, Nadeem Fatteh, Ahmed S. Ibrahim

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. Adenosine and its receptors have been shown to possess anti-inflammatory properties that have only recently been studied in DR. Here, we review recent studies that determined the roles of adenosine and its associated proteins, including equilibrative nucleoside transporters, adenosine receptors, and underlying signaling pathways in retinal complications associated with diabetes.

Original language	English (US)
Pages (from-to)	19-24
Number of pages	6
Journal	Journal of Ocular Biology, Diseases, and Informatics
Volume	4
Issue number	1-2
DOIs	https://doi.org/10.1007/s12177-011-9067-5
State	Published - Jun 2011
Externally published	Yes

Keywords

Adenosine
Adenosine receptors
Cannabinoids
Diabetic retinopathy
Microglia

ASJC Scopus subject areas

Ophthalmology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12177-011-9067-5

Cite this

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title = "Role of adenosine in diabetic retinopathy",

abstract = "In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. Adenosine and its receptors have been shown to possess anti-inflammatory properties that have only recently been studied in DR. Here, we review recent studies that determined the roles of adenosine and its associated proteins, including equilibrative nucleoside transporters, adenosine receptors, and underlying signaling pathways in retinal complications associated with diabetes.",

keywords = "Adenosine, Adenosine receptors, Cannabinoids, Diabetic retinopathy, Microglia",

author = "Liou, {Gregory I.} and Saif Ahmad and Mohammad Naime and Nadeem Fatteh and Ibrahim, {Ahmed S.}",

note = "Funding Information: This work has been supported by Vision Discovery Institute (GIL), Department of Defense (GIL), and Egyptian Cultural and Educational Bureau (ASI). G.I.Liou(*).S.Ahmad.M.Naime.N.Fatteh Department of Ophthalmology, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA e-mail: giliou@georgiahealth.edu",

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doi = "10.1007/s12177-011-9067-5",

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AU - Liou, Gregory I.

AU - Ahmad, Saif

AU - Naime, Mohammad

AU - Fatteh, Nadeem

AU - Ibrahim, Ahmed S.

N1 - Funding Information: This work has been supported by Vision Discovery Institute (GIL), Department of Defense (GIL), and Egyptian Cultural and Educational Bureau (ASI). G.I.Liou(*).S.Ahmad.M.Naime.N.Fatteh Department of Ophthalmology, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA e-mail: giliou@georgiahealth.edu

PY - 2011/6

Y1 - 2011/6

N2 - In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. Adenosine and its receptors have been shown to possess anti-inflammatory properties that have only recently been studied in DR. Here, we review recent studies that determined the roles of adenosine and its associated proteins, including equilibrative nucleoside transporters, adenosine receptors, and underlying signaling pathways in retinal complications associated with diabetes.

AB - In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. Adenosine and its receptors have been shown to possess anti-inflammatory properties that have only recently been studied in DR. Here, we review recent studies that determined the roles of adenosine and its associated proteins, including equilibrative nucleoside transporters, adenosine receptors, and underlying signaling pathways in retinal complications associated with diabetes.

KW - Adenosine

KW - Adenosine receptors

KW - Cannabinoids

KW - Diabetic retinopathy

KW - Microglia

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JF - Journal of Ocular Biology, Diseases, and Informatics

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Role of adenosine in diabetic retinopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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