Role of Ca2+ channels in short-term synaptic plasticity

Jianhua Xu, Liming He, Ling Gang Wu

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Repetitive nerve activity induces various forms of short-term synaptic plasticity that have important computational roles in neuronal networks. Several forms of short-term plasticity are caused largely by changes in transmitter release, but the mechanisms that underlie these changes in the release process have been difficult to address. Recent studies of a giant synapse - the calyx of Held - have shed new light on this issue. Recordings of Ca2+ currents or Ca2+ concentrations at nerve terminals reveal that regulation of presynaptic Ca2+ channels has a significant role in three important forms of short-term plasticity: short-term depression, facilitation and post-tetanic potentiation.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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