Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex

Zubair A. Karim, Nicole R. Hensch, Hanan Qasim, Fatima Z. Alshbool, Fadi T. Khasawneh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The current work investigates the notion that inducible clustering of signaling mediators of the IKK pathway is important for platelet activation. Thus, while the CARMA1, Bcl10, and MALT1 (CBM) complex is essential for triggering IKK/NF-κB activation upon platelet stimulation, the signals that elicit its formation and downstream effector activation remain elusive. We demonstrate herein that IKKβ is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. We also show that IKKβ regulates these processes via modulation of phosphorylation of Bcl10 and IKKγ polyubiquitination. Collectively, our data demonstrate that IKKβ regulates membrane fusion and the remodeling of the CBM complex formation.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jun 2 2018
Externally publishedYes


  • CBM complex
  • IKKβ
  • SNARE machinery
  • Ubiquitination

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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