Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha, Allyson E. Koyen, Ashley J. Schlafstein, David S. Yu

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Original languageEnglish (US)
Title of host publicationRole of Transcription Factors in Gastrointestinal Malignancies
PublisherSpringer Singapore
Number of pages10
ISBN (Electronic)9789811067280
ISBN (Print)9789811067273
StatePublished - Jan 1 2018
Externally publishedYes


  • Immunotherapy
  • Pancreatic cancer
  • STAT3

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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