Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha; Allyson E. Koyen; Ashley J. Schlafstein; David S. Yu

doi:10.1007/978-981-10-6728-0_24

Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha, Allyson E. Koyen, Ashley J. Schlafstein, David S. Yu

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Original language	English (US)
Title of host publication	Role of Transcription Factors in Gastrointestinal Malignancies
Publisher	Springer Singapore
Pages	339-348
Number of pages	10
ISBN (Electronic)	9789811067280
ISBN (Print)	9789811067273
DOIs	https://doi.org/10.1007/978-981-10-6728-0_24
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Immunotherapy
Pancreatic cancer
STAT3

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-10-6728-0_24

Cite this

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abstract = "STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.",

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T2 - A target for therapy

AU - Daddacha, Waaqo B.

AU - Koyen, Allyson E.

AU - Schlafstein, Ashley J.

AU - Yu, David S.

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AB - STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

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KW - Pancreatic cancer

KW - STAT3

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BT - Role of Transcription Factors in Gastrointestinal Malignancies

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Role of STAT3 in Pancreatic Cancer: A target for therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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