Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha; Allyson E. Koyen; Ashley J. Schlafstein; David S. Yu

doi:10.1007/978-981-10-6728-0_24

Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha
, Allyson E. Koyen
, Ashley J. Schlafstein
, David S. Yu

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Original language	English (US)
Title of host publication	Role of Transcription Factors in Gastrointestinal Malignancies
Publisher	Springer Singapore
Pages	339-348
Number of pages	10
ISBN (Electronic)	9789811067280
ISBN (Print)	9789811067273
DOIs	https://doi.org/10.1007/978-981-10-6728-0_24
State	Published - Jan 1 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Immunotherapy
Pancreatic cancer
STAT3

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-981-10-6728-0_24

Cite this

@inbook{5b4b6c237ce24d839f5a9af74fc6eb38,

title = "Role of STAT3 in Pancreatic Cancer: A target for therapy",

abstract = "STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.",

keywords = "Immunotherapy, Pancreatic cancer, STAT3",

author = "Daddacha, \{Waaqo B.\} and Koyen, \{Allyson E.\} and Schlafstein, \{Ashley J.\} and Yu, \{David S.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017.",

year = "2018",

month = jan,

day = "1",

doi = "10.1007/978-981-10-6728-0\_24",

language = "English (US)",

isbn = "9789811067273",

pages = "339--348",

booktitle = "Role of Transcription Factors in Gastrointestinal Malignancies",

publisher = "Springer Singapore",

address = "Singapore",

}

TY - CHAP

T1 - Role of STAT3 in Pancreatic Cancer

T2 - A target for therapy

AU - Daddacha, Waaqo B.

AU - Koyen, Allyson E.

AU - Schlafstein, Ashley J.

AU - Yu, David S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

AB - STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

KW - Immunotherapy

KW - Pancreatic cancer

KW - STAT3

UR - https://www.scopus.com/pages/publications/85046479235

UR - https://www.scopus.com/pages/publications/85046479235#tab=citedBy

U2 - 10.1007/978-981-10-6728-0_24

DO - 10.1007/978-981-10-6728-0_24

M3 - Chapter

AN - SCOPUS:85046479235

SN - 9789811067273

SP - 339

EP - 348

BT - Role of Transcription Factors in Gastrointestinal Malignancies

PB - Springer Singapore

ER -

Role of STAT3 in Pancreatic Cancer: A target for therapy

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this