Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Joo Sung Kim; Jiaqi Li; If H.A. Barnes; David A. Baltzegar; Mohanasundari Pajaniappan; Thomas W. Cullen; M. Stephen Trent; Christopher M. Burns; Stuart A Thompson

doi:10.1128/JB.00765-08

Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Joo Sung Kim
, Jiaqi Li
, If H.A. Barnes
, David A. Baltzegar
, Mohanasundari Pajaniappan
, Thomas W. Cullen
, M. Stephen Trent
, Christopher M. Burns
, Stuart A Thompson

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

Original language	English (US)
Pages (from-to)	6524-6529
Number of pages	6
Journal	Journal of Bacteriology
Volume	190
Issue number	19
DOIs	https://doi.org/10.1128/JB.00765-08
State	Published - Oct 2008

ASJC Scopus subject areas

Microbiology
Molecular Biology

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title = "Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics",

abstract = "Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.",

author = "Kim, \{Joo Sung\} and Jiaqi Li and Barnes, \{If H.A.\} and Baltzegar, \{David A.\} and Mohanasundari Pajaniappan and Cullen, \{Thomas W.\} and Trent, \{M. Stephen\} and Burns, \{Christopher M.\} and Thompson, \{Stuart A\}",

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AU - Kim, Joo Sung

AU - Li, Jiaqi

AU - Barnes, If H.A.

AU - Baltzegar, David A.

AU - Pajaniappan, Mohanasundari

AU - Cullen, Thomas W.

AU - Trent, M. Stephen

AU - Burns, Christopher M.

AU - Thompson, Stuart A

PY - 2008/10

Y1 - 2008/10

N2 - Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

AB - Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

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UR - https://www.scopus.com/pages/publications/52649142713#tab=citedBy

U2 - 10.1128/JB.00765-08

DO - 10.1128/JB.00765-08

M3 - Article

C2 - 18689478

AN - SCOPUS:52649142713

SN - 0021-9193

VL - 190

SP - 6524

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

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ER -

Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Abstract

ASJC Scopus subject areas

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