TY - JOUR
T1 - Role of tumor-associated gangliosides in cancer progression
AU - Birklé, S.
AU - Zeng, G.
AU - Gao, L.
AU - Yu, R. K.
AU - Aubry, J.
N1 - Funding Information:
Work in the laboratory of the authors was supported by National Institute of Health grants NS 11853, American Cancer Society grant IRG-105, and US Public Health Service grant NS11853-24. SB was also supported by a fellowship from the Fondation pour la Recherche Médicale, the Ligue Contre le Cancer, and the Groupement des Entreprises Françaises dans la Lutte contre le Cancer.
PY - 2003
Y1 - 2003
N2 - Neuroectodermic tumors can mostly be characterized by the presence of tumor-associated glycosphingolipid antigens, such as gangliosides, defined by monoclonal antibodies. Recently, cumulative evidence indicates that gangliosides modify the biological effects of several trophic factors, in vitro and in vivo, as well as the mitogenic signaling cascade that these factors generate. The functional roles of gangliosides in tumor progression can be revisited: (i) ganglioside antigens on the cell surface, or shed from the cells, act as immunosuppressors, as typically observed for the suppression of cytotoxic T cells and dendritic cells, (ii) certain gangliosides, such as GD3 or GM2, promote tumor-associated angiogenesis, (iii) gangliosides strongly regulate cell adhesion/motility and thus initiate tumor metastasis, (iv) ganglioside antigens are directly connected with transducer molecules in microdomains to initiate adhesion coupled with signaling, and (v) ganglioside antigens and their- catabolites are modulators of signal transduction through interaction with tyrosine kinases associated with growth factor receptors or other protein kinases. Given the potential importance of these sialylated gangliosides and their modulating biological behavior in vivo, further studies on the role of gangliosides are warranted.
AB - Neuroectodermic tumors can mostly be characterized by the presence of tumor-associated glycosphingolipid antigens, such as gangliosides, defined by monoclonal antibodies. Recently, cumulative evidence indicates that gangliosides modify the biological effects of several trophic factors, in vitro and in vivo, as well as the mitogenic signaling cascade that these factors generate. The functional roles of gangliosides in tumor progression can be revisited: (i) ganglioside antigens on the cell surface, or shed from the cells, act as immunosuppressors, as typically observed for the suppression of cytotoxic T cells and dendritic cells, (ii) certain gangliosides, such as GD3 or GM2, promote tumor-associated angiogenesis, (iii) gangliosides strongly regulate cell adhesion/motility and thus initiate tumor metastasis, (iv) ganglioside antigens are directly connected with transducer molecules in microdomains to initiate adhesion coupled with signaling, and (v) ganglioside antigens and their- catabolites are modulators of signal transduction through interaction with tyrosine kinases associated with growth factor receptors or other protein kinases. Given the potential importance of these sialylated gangliosides and their modulating biological behavior in vivo, further studies on the role of gangliosides are warranted.
KW - Adhesion
KW - Angiogenesis
KW - Ganglioside
KW - Immunomodulation
KW - Tumorigenesis
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U2 - 10.1016/S0300-9084(03)00006-3
DO - 10.1016/S0300-9084(03)00006-3
M3 - Review article
C2 - 12770784
AN - SCOPUS:0038532523
SN - 0300-9084
VL - 85
SP - 455
EP - 463
JO - Biochimie
JF - Biochimie
IS - 3-4
ER -