TY - JOUR
T1 - Sapota fruit latex mediated synthesis of Ag, Cu mono and bimetallic nanoparticles and their in vitro toxicity studies
AU - Thakore, Sonal I.
AU - Nagar, Padamanabhi S.
AU - Jadeja, Ravirajsinh N.
AU - Thounaojam, Menaka
AU - Devkar, Ranjitsinh V.
AU - Rathore, Puran Singh
N1 - Funding Information:
One of the authors (MV) is grateful to CSIR, New Delhi, for senior research fellowship. Special thanks to Dr. Bhavna Trivedi and Mr. Shardul Bhatt Department of Chemistry, for cyclic voltammetry studies.
Publisher Copyright:
© 2015
PY - 2019/7
Y1 - 2019/7
N2 - Ag, Cu metallic and bimetallic nanoparticles (NPs) with diverse compositions were efficiently synthesized using the fruit latex of Achras sapota Linn. Spectroscopic and cyclic voltammetry results suggested that reduction of Ag was assisted by ascorbic acid, reducing sugars and other phenolic compounds present in the latex. However, the reduction of Cu and alloy NPs required additional ascorbic acid. Comparative in vitro toxicity of as synthesized nanoparticle solution was assessed in 3T3L1 cells using MTT assay and fluorescent microscopy. A minimal impact was observed on cell viability and morphology during 72 h. This demonstrates great potential for use in biomedical applications such as cellular imaging or photothermal therapy.
AB - Ag, Cu metallic and bimetallic nanoparticles (NPs) with diverse compositions were efficiently synthesized using the fruit latex of Achras sapota Linn. Spectroscopic and cyclic voltammetry results suggested that reduction of Ag was assisted by ascorbic acid, reducing sugars and other phenolic compounds present in the latex. However, the reduction of Cu and alloy NPs required additional ascorbic acid. Comparative in vitro toxicity of as synthesized nanoparticle solution was assessed in 3T3L1 cells using MTT assay and fluorescent microscopy. A minimal impact was observed on cell viability and morphology during 72 h. This demonstrates great potential for use in biomedical applications such as cellular imaging or photothermal therapy.
KW - Alloy nanoparticles
KW - Cytotoxicity
KW - Latex
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U2 - 10.1016/j.arabjc.2014.12.042
DO - 10.1016/j.arabjc.2014.12.042
M3 - Article
AN - SCOPUS:85067587088
SN - 1878-5352
VL - 12
SP - 694
EP - 700
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
IS - 5
ER -