Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

Vinata B. Lokeshwar; Mark S. Soloway; Norman L. Block

doi:10.1016/S0304-3835(98)00197-9

Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

Vinata B. Lokeshwar, Mark S. Soloway, Norman L. Block

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	21-27
Number of pages	7
Journal	Cancer Letters
Volume	131
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(98)00197-9
State	Published - Sep 11 1998
Externally published	Yes

Keywords

Bladder cancer marker
Hyaluronic acid
Hyaluronidase
Tumor angiogenesis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(98)00197-9

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title = "Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells",

abstract = "Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

keywords = "Bladder cancer marker, Hyaluronic acid, Hyaluronidase, Tumor angiogenesis",

author = "Lokeshwar, {Vinata B.} and Soloway, {Mark S.} and Block, {Norman L.}",

note = "Funding Information: We gratefully acknowledge the help of all the residents and staff of the Department of Urology for collecting specimens for this study. This work was supported by NCI grant R29 CA 72821 (V.B.L.) and L. Austin Weeks Endowment funds (N.L.B. and V.B.L.).",

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doi = "10.1016/S0304-3835(98)00197-9",

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AU - Lokeshwar, Vinata B.

AU - Soloway, Mark S.

AU - Block, Norman L.

N1 - Funding Information: We gratefully acknowledge the help of all the residents and staff of the Department of Urology for collecting specimens for this study. This work was supported by NCI grant R29 CA 72821 (V.B.L.) and L. Austin Weeks Endowment funds (N.L.B. and V.B.L.).

PY - 1998/9/11

Y1 - 1998/9/11

N2 - Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Bladder cancer marker

KW - Hyaluronic acid

KW - Hyaluronidase

KW - Tumor angiogenesis

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Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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