Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

Vinata B. Lokeshwar, Mark S. Soloway, Norman L. Block

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalCancer Letters
Issue number1
StatePublished - Sep 11 1998
Externally publishedYes


  • Bladder cancer marker
  • Hyaluronic acid
  • Hyaluronidase
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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