1. 1. The novel choline analogs selenonium choline (SeCh) and acetylselenonium choline (ASeCh) have been examined for selected biological activities. 2. 2. ASeCh was found to be an alternative substrate for acetylcholin esterase with Km and Vmax values similar to acetylcholine. 3. 3. ASeCh and SeCh inhibited acetylthiocholine hydrolysis by acetylcholinesterase with IC50 values similar to acetylcholine and choline. 4. 4. SeCh exerted a protective action against physostigmine and DFP induced toxicity. 5. 5. SeCh (85 mg/kg) was found to be 3 times more toxic in mice than choline.
ASJC Scopus subject areas