TY - JOUR
T1 - SELECTIVE IMMUNODEFICIENCY AFFECTING STAPHYLOCOCCAL RESPONSE
AU - Monteil, Michele
AU - Hobbs, John
AU - Citron, Kenneth
N1 - Funding Information:
This work was supported by the Dobson and Immunology
PY - 1987/10/17
Y1 - 1987/10/17
N2 - Eight patients with recurrent staphylococcal infections, necessitating up to 213 hospital admissions in one patient, gave normal results with the usual immunological investigations, including measurement of serum IgG and IgG2. In the staphylococcal inhibition test all showed persistently subnormal results, corrected by the addition of compatible normal plasma or normal IgG therapy for 6 months to 21 years, and one died from staphylococcal septicaemia 6 months after withdrawal of treatment. The impairment in anti-staphylococcal response, with failure to produce adequate antibodies, was probably acquired in utero in four patients and inherited in two. In these six patients symptoms started soon after 4 months. In the remaining two the syndrome was acquired later in life.
AB - Eight patients with recurrent staphylococcal infections, necessitating up to 213 hospital admissions in one patient, gave normal results with the usual immunological investigations, including measurement of serum IgG and IgG2. In the staphylococcal inhibition test all showed persistently subnormal results, corrected by the addition of compatible normal plasma or normal IgG therapy for 6 months to 21 years, and one died from staphylococcal septicaemia 6 months after withdrawal of treatment. The impairment in anti-staphylococcal response, with failure to produce adequate antibodies, was probably acquired in utero in four patients and inherited in two. In these six patients symptoms started soon after 4 months. In the remaining two the syndrome was acquired later in life.
UR - http://www.scopus.com/inward/record.url?scp=0023618158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023618158&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(87)91372-9
DO - 10.1016/S0140-6736(87)91372-9
M3 - Article
C2 - 2889082
AN - SCOPUS:0023618158
SN - 0140-6736
VL - 330
SP - 880
EP - 883
JO - The Lancet
JF - The Lancet
IS - 8564
ER -