Abstract
Non-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses. Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with serine may confer benefits in safeguarding against aging and age-related disorders. This review synthesizes recent insights into the regulation of serine metabolism during aging and its potential to promote healthy lifespan and mitigate a spectrum of age-related diseases.
| Original language | English (US) |
|---|---|
| Article number | e2200130 |
| Pages (from-to) | 611-630 |
| Number of pages | 20 |
| Journal | GeroScience |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2025 |
Keywords
- Age-related diseases
- Aging
- Longevity
- Metabolism
- Oxidative stress
- Serine
ASJC Scopus subject areas
- Aging
- veterinary (miscalleneous)
- Complementary and alternative medicine
- Geriatrics and Gerontology
- Cardiology and Cardiovascular Medicine
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