Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Dara Khosravi; Hannah Soloff; Rose M. Langsjoen; Andrei Bombin; Colleen F. Kelley; Susan M. Ray; Clifford J. Gunthel; Brian C. Zanoni; Phuong Vi Nguyen; Jesse J. Waggoner; Yun F. Wang; Valeria D. Cantos; Anne Piantadosi

doi:10.1093/ofid/ofad054

Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Dara Khosravi
, Hannah Soloff
, Rose M. Langsjoen
, Andrei Bombin
, Colleen F. Kelley
, Susan M. Ray
, Clifford J. Gunthel
, Brian C. Zanoni
, Phuong Vi Nguyen
, Jesse J. Waggoner
, Yun F. Wang
, Valeria D. Cantos
, Anne Piantadosi

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.

Original language	English (US)
Article number	ofad054
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofad054
State	Published - Feb 1 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
SARS-CoV-2
immunocompromised
monoclonal antibody
virus evolution

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofad054

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Khosravi, D., Soloff, H., Langsjoen, R. M., Bombin, A., Kelley, C. F., Ray, S. M., Gunthel, C. J., Zanoni, B. C., Nguyen, P. V., Waggoner, J. J., Wang, Y. F., Cantos, V. D., & Piantadosi, A. (2023). Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV. Open Forum Infectious Diseases, 10(2), Article ofad054. https://doi.org/10.1093/ofid/ofad054

Khosravi, D, Soloff, H, Langsjoen, RM, Bombin, A, Kelley, CF, Ray, SM, Gunthel, CJ, Zanoni, BC, Nguyen, PV, Waggoner, JJ, Wang, YF, Cantos, VD & Piantadosi, A 2023, 'Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV', Open Forum Infectious Diseases, vol. 10, no. 2, ofad054. https://doi.org/10.1093/ofid/ofad054

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abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.",

keywords = "HIV, SARS-CoV-2, immunocompromised, monoclonal antibody, virus evolution",

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doi = "10.1093/ofid/ofad054",

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AU - Bombin, Andrei

AU - Kelley, Colleen F.

AU - Ray, Susan M.

AU - Gunthel, Clifford J.

AU - Zanoni, Brian C.

AU - Nguyen, Phuong Vi

AU - Waggoner, Jesse J.

AU - Wang, Yun F.

AU - Cantos, Valeria D.

AU - Piantadosi, Anne

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AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.

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KW - SARS-CoV-2

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Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape from Combination Monoclonal Antibody Treatment in a Person with HIV

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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