Abstract
Anaphylaxis secondary to thymoglobulin (anti-thymocyte globulin) is a rare condition that can be life threatening. Thymoglobulin is a rabbit-derived T-cell depleting polyclonal immunoglobulin. It is commonly used for induction immunosuppression and/or for treatment of acute rejection in renal transplantation. We report a case of a living kidney transplant recipient who developed intraoperative anaphylactic shock secondary to thymoglobulin. The patient had a history of pet rabbit exposure. This case report highlights the importance of prompt identification and management of intraoperative anaphylaxis, which is key to a successful outcome. Induction immunosuppression selection based on patient characteristics is important. Communication between the anesthesia team and surgeons played a key role in stopping the donor surgery.
Original language | English (US) |
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Article number | 43 |
Pages (from-to) | 1-5 |
Number of pages | 5 |
Journal | Antibodies |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2020 |
Keywords
- Anaphylactic shock
- Living donor kidney transplantation
- Rabbit anti-thymocyte globulin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Drug Discovery