Sideroblastic Anemia

Yulan Jin; Natasha M. Savage

doi:10.1007/978-3-031-62373-8_11

Sideroblastic Anemia

Yulan Jin, Natasha M. Savage

Clinical Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Sideroblastic anemia (SA) is a familial or congenital or acquired anemia, which represents a diverse group of disorders characterized by increased ring sideroblasts in bone marrow. Ring sideroblasts are erythroblasts with pathogenic iron-laden mitochondria encircling their nucleus. Morphologically, ring sideroblasts are defined by having a minimum of 5 siderotic granules covering at least one-third of the circumference of the nucleus of erythroblasts. Ring sideroblasts should be distinguished from sideroblasts. The latter is iron deposition inside cytoplasm of erythroblasts, usually not riming nuclei and does not meet the above criteria to be called ring sideroblasts.

Original language	English (US)
Title of host publication	Non-Neoplastic Hematologic Disorders
Subtitle of host publication	A Quick Review of Modern Diagnostic and Therapeutic Approaches
Publisher	Springer Nature
Pages	147-158
Number of pages	12
ISBN (Electronic)	9783031623738
DOIs	https://doi.org/10.1007/978-3-031-62373-8_11
State	Published - Jan 1 2024

Keywords

Heme synthesis
Ineffective erythropoiesis
Ring-sideroblasts
Sideroblastic anemia (SA)
Sideroblasts

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-62373-8_11

Cite this

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title = "Sideroblastic Anemia",

abstract = "Sideroblastic anemia (SA) is a familial or congenital or acquired anemia, which represents a diverse group of disorders characterized by increased ring sideroblasts in bone marrow. Ring sideroblasts are erythroblasts with pathogenic iron-laden mitochondria encircling their nucleus. Morphologically, ring sideroblasts are defined by having a minimum of 5 siderotic granules covering at least one-third of the circumference of the nucleus of erythroblasts. Ring sideroblasts should be distinguished from sideroblasts. The latter is iron deposition inside cytoplasm of erythroblasts, usually not riming nuclei and does not meet the above criteria to be called ring sideroblasts.",

keywords = "Heme synthesis, Ineffective erythropoiesis, Ring-sideroblasts, Sideroblastic anemia (SA), Sideroblasts",

author = "Yulan Jin and Savage, \{Natasha M.\}",

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AU - Savage, Natasha M.

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PY - 2024/1/1

Y1 - 2024/1/1

N2 - Sideroblastic anemia (SA) is a familial or congenital or acquired anemia, which represents a diverse group of disorders characterized by increased ring sideroblasts in bone marrow. Ring sideroblasts are erythroblasts with pathogenic iron-laden mitochondria encircling their nucleus. Morphologically, ring sideroblasts are defined by having a minimum of 5 siderotic granules covering at least one-third of the circumference of the nucleus of erythroblasts. Ring sideroblasts should be distinguished from sideroblasts. The latter is iron deposition inside cytoplasm of erythroblasts, usually not riming nuclei and does not meet the above criteria to be called ring sideroblasts.

AB - Sideroblastic anemia (SA) is a familial or congenital or acquired anemia, which represents a diverse group of disorders characterized by increased ring sideroblasts in bone marrow. Ring sideroblasts are erythroblasts with pathogenic iron-laden mitochondria encircling their nucleus. Morphologically, ring sideroblasts are defined by having a minimum of 5 siderotic granules covering at least one-third of the circumference of the nucleus of erythroblasts. Ring sideroblasts should be distinguished from sideroblasts. The latter is iron deposition inside cytoplasm of erythroblasts, usually not riming nuclei and does not meet the above criteria to be called ring sideroblasts.

KW - Heme synthesis

KW - Ineffective erythropoiesis

KW - Ring-sideroblasts

KW - Sideroblastic anemia (SA)

KW - Sideroblasts

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M3 - Chapter

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BT - Non-Neoplastic Hematologic Disorders

PB - Springer Nature

ER -

Sideroblastic Anemia

Abstract

Keywords

ASJC Scopus subject areas

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