Signal transduction by a protease cascade

Ellen K. LeMosy; Charles C. Hong; Carl Hashimoto

doi:10.1016/S0962-8924(98)01494-9

Signal transduction by a protease cascade

Ellen K. LeMosy, Charles C. Hong, Carl Hashimoto

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

Original language	English (US)
Pages (from-to)	102-107
Number of pages	6
Journal	Trends in Cell Biology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/S0962-8924(98)01494-9
State	Published - Mar 1 1999
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1016/S0962-8924(98)01494-9

Cite this

@article{0ed435fb086e425b8477ec1b9d271f6f,

title = "Signal transduction by a protease cascade",

abstract = "The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.",

author = "LeMosy, {Ellen K.} and Hong, {Charles C.} and Carl Hashimoto",

note = "Funding Information: We thank Laura Mitic and Karen Ross for critical reading of the manuscript and gratefully acknowledge financial support from the American Heart Association and the NIH. ",

year = "1999",

month = mar,

day = "1",

doi = "10.1016/S0962-8924(98)01494-9",

language = "English (US)",

volume = "9",

pages = "102--107",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Signal transduction by a protease cascade

AU - LeMosy, Ellen K.

AU - Hong, Charles C.

AU - Hashimoto, Carl

N1 - Funding Information: We thank Laura Mitic and Karen Ross for critical reading of the manuscript and gratefully acknowledge financial support from the American Heart Association and the NIH.

PY - 1999/3/1

Y1 - 1999/3/1

N2 - The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

AB - The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

UR - http://www.scopus.com/inward/record.url?scp=0033106265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033106265&partnerID=8YFLogxK

U2 - 10.1016/S0962-8924(98)01494-9

DO - 10.1016/S0962-8924(98)01494-9

M3 - Review article

C2 - 10201075

AN - SCOPUS:0033106265

SN - 0962-8924

VL - 9

SP - 102

EP - 107

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 3

ER -

Signal transduction by a protease cascade

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this