Signal transduction by a protease cascade

Ellen K. LeMosy, Charles C. Hong, Carl Hashimoto

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalTrends in Cell Biology
Issue number3
StatePublished - Mar 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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