@article{3fcbb8dd8c8c4bd895ef4a8ddfb66ae4,
title = "Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway",
abstract = "The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs). Two of the Slit-Robo GAPs (srGAPs) are expressed in regions responsive to Slit. Slit increased srGAP1-Robo1 interaction and inactivated Cdc42. A dominant negative srGAP1 blocked Slit inactivation of Cdc42 and Slit repulsion of migratory cells from the anterior subventricular zone (SVZa) of the forebrain. A constitutively active Cdc42 blocked the repulsive effect of Slit. These results have demonstrated important roles for GAPs and Cdc42 in neuronal migration. We propose a signal transduction pathway from the extracellular guidance cue to intracellular actin polymerization.",
author = "Kit Wong and Ren, {Xiu Rong} and Huang, {Yang Zhong} and Yi Xie and Guofa Liu and Harumi Saito and Hao Tang and Leng Wen and Brady-Kalnay, {Susann M.} and Lin Mei and Wu, {Jane Y.} and Wencheng Xiong and Yi Rao",
note = "Funding Information: We are grateful to Elizabeth J. Rao for assistance; to Dr. J. Bamburg for adenoviral constructs; to Drs. Bernhard Mueller and John Collard for GST fusion proteins; Dr. Takahiro Nagase for KIAA plasmids; to Dr. Jeff Chamberlain for cDNA libraries; to Dr. Gary Nolan for providing the retrovirus system; to Adam Grasso and Jullia Rosdahl for assistance with the retroviruses; to the NIH (to Y.R., S.B.K., J.Y.W., and L.M.), the American Heart Association (Southeastern Division) (to W-C.X.), the Muscular Dystrophy Association and HHMI/UAB Faculty Development Award (to L.M.) for support; to the John Merck Fund, the Klingenstein Foundation, and the Leukemia Society of America for scholar awards (to Y.R. and J.Y.W.). We apologize for citation of reviews instead of original papers due to space constraints. ",
year = "2001",
month = oct,
day = "19",
doi = "10.1016/S0092-8674(01)00530-X",
language = "English (US)",
volume = "107",
pages = "209--221",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}