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Sildenafil normalizes bowel transit in preclinical models of constipation
Sarah K. Sharman
, Bianca N. Islam
, Yali Hou
, Margaux Usry
, Allison Bridges
,
Nagendra Singh
, Subbaramiah Sridhar
,
Satish Rao
,
Darren D. Browning
Biological Sciences
Biochemistry and Molecular Biology
Gastroenterology
Research output
:
Contribution to journal
›
Article
›
peer-review
15
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Scopus citations
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Keyphrases
Constipation
100%
Bowel
100%
Sildenafil
100%
Cyclic GMP
87%
Linaclotide
62%
Fecal Water Content
37%
Guanylyl Cyclase C Agonists
37%
Functional Constipation
25%
Intestine
25%
Intestinal Epithelium
25%
Irritable Bowel Syndrome
25%
Dextran Sulfate Sodium
25%
Pediatric Patients
12%
Therapeutic Benefits
12%
Colitis
12%
Water Content
12%
Days of Treatment
12%
Oral Administration
12%
Motility Disorders
12%
Colon mucosa
12%
Maximal Effect
12%
PDE5 Inhibitors
12%
Gastrointestinal Transit
12%
Common Target
12%
Epithelial Barrier
12%
Healthy Mice
12%
Acute Dose
12%
Disordered Models
12%
Slow Transit
12%
Postinfectious IBS
12%
Target Pathways
12%
Loperamide-induced Constipation
12%
Sodium Recovery
12%
Fecal Pellets
12%
Medicine and Dentistry
Constipation
100%
Sildenafil
100%
Linaclotide
62%
Heat Stable Enterotoxin Receptor Agonist
37%
Intestine
25%
Irritable Bowel Syndrome
25%
Gut
25%
Intestinal Epithelium
25%
Dextran Sulfate
25%
Disease
12%
Pediatrics Patient
12%
Secretion (Process)
12%
Oral Drug Administration
12%
Loperamide
12%
Colitis
12%
Phosphodiesterase V Inhibitor
12%
Colon Mucosa
12%
Pharmacology, Toxicology and Pharmaceutical Science
Constipation
100%
Sildenafil
100%
Linaclotide
62%
Heat Stable Enterotoxin Receptor Agonist
37%
Mouse
25%
Irritable Colon
25%
Dextran Sulfate
25%
Disease
12%
Mouse Model
12%
Colitis
12%
Phosphodiesterase V Inhibitor
12%
Loperamide
12%