Abstract
Leukocyte recruitment into sites of inflammation involves a complex cascade of molecular interactions between the leukocyte and the endothelial cells of the inflamed venule. This report proposes a novel agent-oriented approach for simulating leukocyte-venule interactions during inflammation. We focus on modeling and simulating the initial steps of rolling, activation, and firm adhesion of neutrophils on TNF-α-treated mouse cremaster muscle venules.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4978-4981 |
| Number of pages | 4 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 26 VII |
| State | Published - 2004 |
| Event | Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004 |
Keywords
- Adhesion
- Agent-Based Model
- Endothelium
- Inflammation
- Leukocyte
- Rolling
- Transmigration
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics