Simultaneous Regeneration of Bone and Nerves Through Materials and Architectural Design: Are We There Yet?

Qian Qian Wan, Wen Pin Qin, Min Juan Shen, Yu Xuan Ma, Bei Li, Shi Yu Liu, Franklin R. Tay, Kai Jiao, Li na Niu

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Bilateral communication between bone and nerves is crucial for optimal repair of large bone defects as well as repair of peripheral nerves within the skeleton. However, simultaneous regeneration of bone and nerves is an issue that has long been overlooked in prior literature. Incongruous or even contradictory requirements or regeneration environments for bone and nerves make simultaneous regeneration of multiple tissues challenging. The present review commences with introducing natural crosstalk between bone and nerves, highlighting the rationale for simultaneous regeneration of bone and nerves. These issues will pave the way for the development of inspirational materials design concepts that capitalize on the principles of osteoconduction, osteoinduction, neuroconduction, neuroinduction, and neuroattraction. Potential strategies based on selection of appropriate scaffolds, acellular biological factors and architectural design will be addressed.

Original languageEnglish (US)
Article number2003542
JournalAdvanced Functional Materials
Issue number48
StatePublished - Nov 25 2020


  • architectural design
  • bone regeneration
  • material design
  • nerve regeneration
  • simultaneous regeneration

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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