SIRT1 in cardiovascular aging

Xin Yuan Luo; Shun Lin Qu; Zhi Han Tang; Yuan Zhang; Mi Hua Liu; Juan Peng; Hui Tang; Kang Lun Yu; Chi Zhang; Zhong Ren; Zhi Sheng Jiang

doi:10.1016/j.cca.2014.07.019

SIRT1 in cardiovascular aging

Xin Yuan Luo
, Shun Lin Qu
, Zhi Han Tang
, Yuan Zhang
, Mi Hua Liu
, Juan Peng
, Hui Tang
, Kang Lun Yu
, Chi Zhang
, Zhong Ren
, Zhi Sheng Jiang

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD⁺-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stress and inflammation, and induction of autophagy. We also demonstrate that moderate up-regulation or activation of SIRT1 in cardiovascular aging and age-related CVD may confer important application values.

Original language	English (US)
Pages (from-to)	106-114
Number of pages	9
Journal	Clinica Chimica Acta
Volume	437
DOIs	https://doi.org/10.1016/j.cca.2014.07.019
State	Published - Nov 1 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-aging strategies
Autophagy
Cardiovascular aging
Inflammation
Oxidative stress
SIRT1

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1016/j.cca.2014.07.019

Cite this

@article{303b49573d4a4f509b18d8c003e664f5,

title = "SIRT1 in cardiovascular aging",

abstract = "Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD+-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stress and inflammation, and induction of autophagy. We also demonstrate that moderate up-regulation or activation of SIRT1 in cardiovascular aging and age-related CVD may confer important application values.",

keywords = "Anti-aging strategies, Autophagy, Cardiovascular aging, Inflammation, Oxidative stress, SIRT1",

author = "Luo, \{Xin Yuan\} and Qu, \{Shun Lin\} and Tang, \{Zhi Han\} and Yuan Zhang and Liu, \{Mi Hua\} and Juan Peng and Hui Tang and Yu, \{Kang Lun\} and Chi Zhang and Zhong Ren and Jiang, \{Zhi Sheng\}",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.cca.2014.07.019",

language = "English (US)",

volume = "437",

pages = "106--114",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - SIRT1 in cardiovascular aging

AU - Luo, Xin Yuan

AU - Qu, Shun Lin

AU - Tang, Zhi Han

AU - Zhang, Yuan

AU - Liu, Mi Hua

AU - Peng, Juan

AU - Tang, Hui

AU - Yu, Kang Lun

AU - Zhang, Chi

AU - Ren, Zhong

AU - Jiang, Zhi Sheng

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD+-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stress and inflammation, and induction of autophagy. We also demonstrate that moderate up-regulation or activation of SIRT1 in cardiovascular aging and age-related CVD may confer important application values.

AB - Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD+-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stress and inflammation, and induction of autophagy. We also demonstrate that moderate up-regulation or activation of SIRT1 in cardiovascular aging and age-related CVD may confer important application values.

KW - Anti-aging strategies

KW - Autophagy

KW - Cardiovascular aging

KW - Inflammation

KW - Oxidative stress

KW - SIRT1

UR - https://www.scopus.com/pages/publications/84905267064

UR - https://www.scopus.com/pages/publications/84905267064#tab=citedBy

U2 - 10.1016/j.cca.2014.07.019

DO - 10.1016/j.cca.2014.07.019

M3 - Review article

C2 - 25063737

AN - SCOPUS:84905267064

SN - 0009-8981

VL - 437

SP - 106

EP - 114

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

SIRT1 in cardiovascular aging

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this