TY - JOUR
T1 - Small GTPase regulation of GPCR anterograde trafficking
AU - Wang, Guansong
AU - Wu, Guangyu
N1 - Funding Information:
This work was supported by National Institutes of Health Grant R01GM076167 (to G. Wu) and National Natural Science Foundation of China Grant 30971309 (to G. Wang).
PY - 2012/1
Y1 - 2012/1
N2 - The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.
AB - The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.
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U2 - 10.1016/j.tips.2011.09.002
DO - 10.1016/j.tips.2011.09.002
M3 - Review article
C2 - 22015208
AN - SCOPUS:84855791190
SN - 0165-6147
VL - 33
SP - 28
EP - 34
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -