Somatic recombination in a murine T-cell receptor gene

A putative T-cell receptor gene was isolated from the DNA of the helper hybridoma, 2B4. Analysis of the sequence components of this rearranged gene indicates the presence of separate variable (V), diversity (D) and joining (J) region elements analogous to those of heavy-chain immunoglobulins. These findings further support the belief that the products of this locus are involved in antigen recognition by T cells. There is no evidence of somatic mutation between the putative germ-line and the expressed variable-region gene.