Sonographic measurements of fetal parts to predict pulmonary maturity among twins and singletons.

S. P. Chauhan, E. F. Magann, J. C. Morrison, A. D. Gunter, N. S. Whitworth, Lawrence D Devoe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


To determine if sonographic examination of fetus can be readily utilized to predict a mature lecithin/sphingomyelin (L/S) ratio among twins and singletons. Twins (n = 36) undergoing amniocentesis for assessment of pulmonary maturity were matched with singleton (1:2) for maternal demographics, gestational age (GA), and indications for procedure. At the time of amniocentesis, twins and singletons with mature L/S ratios differed significantly in mean GA (33.2 +/- 2.7 vs 34.5 +/- 4.6 wks, p = 0.01), biparietal diameter (BPD), abdominal circumference (AC), femur length (FL) and estimate of birth weight (EFW). Based on ten receiver operating characteristics curves constructed, the following diagnostic thresholds predicted a mature L/S ratio with a true positive rate of 100% among twins and singletons, respectively: 1) BPD $84 and $92 mm; 2) head circumference $315 and $320 mm; 3) AC $295 and $350 mm; or 4) FL $64 and $72 mm; or 5) EFW $2400 and $3200 g. Using any one of these five criteria correctly identified pulmonary maturity among 59% of twins and 28% of singletons (p = 0.001). Sonographic measurement of fetal parts or EFW may be a noninvasive method to predict a mature L/S ration among twins as well as singletons.

Original languageEnglish (US)
Pages (from-to)516-520
Number of pages5
JournalJournal of the Mississippi State Medical Association
Issue number3
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Medicine(all)


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