Spectroscopic imaging as a triage test for cervical disease: A prospective multicenter clinical trial

Timothy DeSantis, Nahida Chakhtoura, Leo Twiggs, Daron Ferris, Manocher Lashgari, Lisa Flowers, Mark Faupel, Shabbir Bambot, Steven Raab, Edward Wilkinson

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


OBJECTIVE. The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS. Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy visit. Spectroscopy measurements taken over a scan period of 4 minutes and 30 seconds were integrated by a cross-validated pattern recognition model and compared with biopsy results to yield sensitivity and specificity of cervical spectroscopy. RESULTS. The median age of subjects enrolled in the study was 27.7 years. The sensitivity of cervical spectroscopy was 95.1% with a corresponding 55.2% specificity for benign lesions. Several potential confounding factors (eg, mucous, blood, patient motion, ambient light) were examined to determine their potential impact on the accuracy of the test. Ambient light seemed to have the greatest effect, but no single factor contributed significantly to the results. The subjects did not experience any adverse events from undergoing the test. CONCLUSIONS. Spectroscopy of the cervix has the potential to accurately detect cervical moderate and high-grade dysplasia while also reducing the false-positive rate for benign cervices. The test is relatively simple to implement and was well accepted by subjects enrolled in the study.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalJournal of Lower Genital Tract Disease
Issue number1
StatePublished - Jan 1 2007


  • Cancer diagnosis
  • Cervical neoplasia
  • Spectroscopy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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