TY - JOUR
T1 - Spiking Pandemic Potential
T2 - Structural and Immunological Aspects of SARS-CoV-2
AU - Wang, Ying Ting
AU - Landeras-Bueno, Sara
AU - Hsieh, Li En
AU - Terada, Yutaka
AU - Kim, Kenneth
AU - Ley, Klaus
AU - Shresta, Sujan
AU - Saphire, Erica Ollmann
AU - Regla-Nava, Jose Angel
N1 - Funding Information:
We thank Sharon Schendel for critical reading of the manuscript and numerous helpful suggestions. This research was funded by Bill and Melinda Gates Foundation grant # INV-006133 .
Publisher Copyright:
© 2020 The Authors
PY - 2020/8
Y1 - 2020/8
N2 - SARS-Coronavirus-2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), an infectious respiratory disease causing thousands of deaths and overwhelming public health systems. The international spread of SARS-CoV-2 is associated with the ease of global travel, and societal dynamics, immunologic naiveté of the host population, and muted innate immune responses. Based on these factors and the expanding geographic scale of the disease, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic–the first caused by a coronavirus. In this review, we summarize the current epidemiological status of COVID-19 and consider the virological and immunological lessons, animal models, and tools developed in response to prior SARS-CoV and MERS-CoV outbreaks that can serve as resources for development of SARS-CoV-2 therapeutics and vaccines. In particular, we discuss structural insights into the SARS-CoV-2 spike protein, a major determinant of transmissibility, and discuss key molecular aspects that will aid in understanding and fighting this new global threat.
AB - SARS-Coronavirus-2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), an infectious respiratory disease causing thousands of deaths and overwhelming public health systems. The international spread of SARS-CoV-2 is associated with the ease of global travel, and societal dynamics, immunologic naiveté of the host population, and muted innate immune responses. Based on these factors and the expanding geographic scale of the disease, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic–the first caused by a coronavirus. In this review, we summarize the current epidemiological status of COVID-19 and consider the virological and immunological lessons, animal models, and tools developed in response to prior SARS-CoV and MERS-CoV outbreaks that can serve as resources for development of SARS-CoV-2 therapeutics and vaccines. In particular, we discuss structural insights into the SARS-CoV-2 spike protein, a major determinant of transmissibility, and discuss key molecular aspects that will aid in understanding and fighting this new global threat.
KW - COVID-19
KW - SARS-CoV-2
KW - coronavirus
KW - host immune response
KW - pandemic
KW - spike
UR - http://www.scopus.com/inward/record.url?scp=85085923286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085923286&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2020.05.012
DO - 10.1016/j.tim.2020.05.012
M3 - Review article
C2 - 32507543
AN - SCOPUS:85085923286
SN - 0966-842X
VL - 28
SP - 605
EP - 618
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 8
ER -
