Spinal cord injury: A review of current therapy, future treatments, and basic science frontiers

Abhay K. Varma; Arabinda Das; Gerald Wallace; John Barry; Alexey A. Vertegel; Swapan K. Ray; Naren L. Banik

doi:10.1007/s11064-013-0991-6

Spinal cord injury: A review of current therapy, future treatments, and basic science frontiers

Abhay K. Varma, Arabinda Das, Gerald Wallace, John Barry, Alexey A. Vertegel, Swapan K. Ray, Naren L. Banik

Research output: Contribution to journal › Review article › peer-review

192 Scopus citations

Abstract

The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.

Original language	English (US)
Pages (from-to)	895-905
Number of pages	11
Journal	Neurochemical Research
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s11064-013-0991-6
State	Published - May 2013
Externally published	Yes

Keywords

Clinical
Preclinical
Spinal cord injury

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1007/s11064-013-0991-6

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title = "Spinal cord injury: A review of current therapy, future treatments, and basic science frontiers",

abstract = "The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.",

keywords = "Clinical, Preclinical, Spinal cord injury",

author = "Varma, {Abhay K.} and Arabinda Das and Gerald Wallace and John Barry and Vertegel, {Alexey A.} and Ray, {Swapan K.} and Banik, {Naren L.}",

note = "Funding Information: Acknowledgments Completion of this project was made possible by funding from the National Institutes of Neurological Disorders and Stroke (NS-31622, NS-38146, and NS-41088), the South Carolina Spinal Cord Injury Research Fund (SCSCIRF), and Department of Neurosciences (Neurosurgery). Authors thank Casey Holmes for help with the preparation of this manuscript.",

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doi = "10.1007/s11064-013-0991-6",

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journal = "Neurochemical Research",

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AU - Wallace, Gerald

AU - Barry, John

AU - Vertegel, Alexey A.

AU - Ray, Swapan K.

AU - Banik, Naren L.

N1 - Funding Information: Acknowledgments Completion of this project was made possible by funding from the National Institutes of Neurological Disorders and Stroke (NS-31622, NS-38146, and NS-41088), the South Carolina Spinal Cord Injury Research Fund (SCSCIRF), and Department of Neurosciences (Neurosurgery). Authors thank Casey Holmes for help with the preparation of this manuscript.

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N2 - The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.

AB - The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.

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KW - Preclinical

KW - Spinal cord injury

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Spinal cord injury: A review of current therapy, future treatments, and basic science frontiers

Abstract

Keywords

ASJC Scopus subject areas

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