Spirooxindoles as potential pharmacophores

Siva S. Panda; Rachel A. Jones; Praveen Bachawala; Prabhu P. Mohapatra

doi:10.2174/1389557516666160624125108

Spirooxindoles as potential pharmacophores

Siva S. Panda, Rachel A. Jones, Praveen Bachawala, Prabhu P. Mohapatra

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Original language	English (US)
Pages (from-to)	1515-1536
Number of pages	22
Journal	Mini-Reviews in Medicinal Chemistry
Volume	17
Issue number	16
DOIs	https://doi.org/10.2174/1389557516666160624125108
State	Published - Jan 1 2017

Keywords

Biological importance
Chemistry
Heterocycles
Pharmacophores
Spirooxindoles
Synthesis

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1389557516666160624125108

Cite this

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abstract = "Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.",

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T1 - Spirooxindoles as potential pharmacophores

AU - Panda, Siva S.

AU - Jones, Rachel A.

AU - Bachawala, Praveen

AU - Mohapatra, Prabhu P.

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Y1 - 2017/1/1

N2 - Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

AB - Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

KW - Biological importance

KW - Chemistry

KW - Heterocycles

KW - Pharmacophores

KW - Spirooxindoles

KW - Synthesis

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M3 - Review article

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AN - SCOPUS:85032151951

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VL - 17

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EP - 1536

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

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ER -

Spirooxindoles as potential pharmacophores

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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